The Tenderloin at Night by Thomas Edison in 1899 is probably the first exploitation movie of all time. Police, prostitution. alcohol, crime, it's all there in San Francisco's own Tenderloin neighborhood
The film was actually made in West orange, New jersey, but it depicts the Tenderloin in San Francisco 112 years ago
Library of Congress database
Youtube poster claims it's New York's tenderloin, but I'm sticking with the Library of Congress on this one....